Activation of Adrenergic β Receptor by Free FattyAcid Composition
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.
Normal hearts have increased contractility in response to catecholamines. Because several lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte responsiveness to adrenergic stimuli. Cardiomyocytes treated with saturated free fatty acids, ceramide, and diacylglycerol had reduced cellular cAMP response to isoproterenol. This was associated with increased PK...
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ژورنال
عنوان ژورنال: Journal of Computer Chemistry, Japan
سال: 2012
ISSN: 1347-1767,1347-3824
DOI: 10.2477/jccj.2011-0014